Experiment 2: Tablet friability
Objective
To test the friabitily of the chosen tablets
Introduction
The friability test is closely related to tablet hardness
and is designed to evaluate the ability of the tablet to withstand abrasion in
packaging, handling and shipping. It is usually measured by the use of the
Roche friabilator. A number of tablets are weighed and placed in the apparatus
where they are exposed to rolling and repeated shocks as they fall 6 inches in
each turn within the apparatus.
Materials
10 of
chosen tablets
Apparatus
the
Roche friabilator
Procedures
1.
Select 10 tablets and weigh.
2. Put all tablets into the drum of
the tablet abration and friability tester. Set the rate of rotation to 100 rpm, time to 10
minutes and start the operation.
3. At the end of the operation,
remove all the tablets and ensure freedom from dust or powder (use the brush). Reweigh the
tablets. Determine the percentage loss of weight.
4. Compressed tablet
should nor lose more than 1% of its weight.
Result
Weight of tablet
Before after
6.6062 g 6.5628 g
Weight loss = 6.6062g
-6.5628g
= 0.0434 g
Percentage of loss
0.0434 g/ 6.6062g x 100 =
0.66 %
Discussion
After 10 minutes of this treatment or 100
revolutions, the tablets are weighed and the weight compared with the initial
weight. The loss due to abrasion is a measure of the tablet friability. The
value is expressed as a percentage. A maximum weight loss of not more than 1%
of the weight of the tablets being tested during the friability test is
considered generally acceptable and any broken or smashed tablets are not
picked up . Normally, when capping occurs, friability
values are not calculated. A thick tablet may have less tendency to cap whereas
thin tablets of large diameter often show extensive capping, thus indicating
that tablets with greater thickness have reduced internal stress.
Conclusion
The
weight loss of tablet is less than 1% which is 0.66%. this mean that the tablets have good
friability.
References
Aulton, M.E. 2002. Pharmaceutics: The Science of
Dosage form Design. Edinburgh Churchill Livingstone. (pg 441-445)
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